Interview with Donald Knuth: I might as well flame a bit about my personal unhappiness with the current trend toward multicore architecture. [...] I won’t be surprised at all if the whole multithreading idea turns out to be a flop, worse than the "Titanium" approach that was supposed to be so terrific—until it turned out that the wished-for compilers were basically impossible to write.

Let me put it this way: During the past 50 years, I’ve written well over a thousand programs, many of which have substantial size. I can’t think of even five of those programs that would have been enhanced noticeably by parallelism or multithreading.